Renee O'Connor was born February 15, 1971 in Houston, Texas, and raised in the small city of Katy, just west of Houston. She began her acting studies in 1983 at Houston's Alley Theatre, and later attended Houston's High School of the Performing and Visual Arts.
Her professional acting career began in 1989 with starring roles in the serials Teen Angel and Match Point, which were both featured on the Disney Channel's Mickey Mouse Club. That same year, she moved to Los Angeles, where she soon landed a feature role in a Tales from the Crypt segment that marked Arnold Schwarzenegger's directorial debut.
She went on to play Cheryl Ladd's daughter in Danielle Steele's Changes and subsequently landed a starring role in the NBC movie The Flood, in which she played one of a group of students whose lives are suddenly endangered. She later guest-starred as the daughter of a murdered couple in an episode of NYPD Blue.
Reneé later co-starred with Ellen Burstyn and Sheryl Lee in the ABC-TV movie Follow the River, in which she played a young woman captured by Shawnee Indians. Set in 1755, the drama was based on a true story. Afterwards, she starred opposite James Garner as a self-obsessed actress who hires Rockford as her bodyguard in The Rockford Files: Blessing in Disguise. Broadcast in May 1995, this was the second of Garner's two recent Rockford Files reunion movies for CBS-TV.
O'Connor's most recent feature film role was that of Julia Wilkes in Disney's The Adventures of Huck Finn, which also starred Elijah Wood.